Research highlight : AUTOMATED MOTIF EXTRACTION AND CLASSIFICATION IN RNA TERTIARY STRUCTURES
AUTOMATED MOTIF EXTRACTION AND CLASSIFICATION IN RNA TERTIARY STRUCTURES 29 November 2008
Mahassine Djelloul and Alain Denise. RNA December 2008 14:2489-2497.
We used a novel graph-based approach to extract RNA tertiary motifs. We cataloged them all and clustered them using an innovative graph similarity measure. We applied our method to three widely studied structures: Haloarcula marismortui 50S (H.m 50S), Escherichia coli 50S (E. coli 50S), and Thermus thermophilus 16S (T.th 16S) RNAs. We identified 10 known motifs without any prior knowledge of their shapes or positions. We additionally identified four putative new motifs.
